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2:30
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This DNA variant causes sickle cell anemia. But not with the same severity for everyone. Why?
Some people inherit two copies of the exact variant behind sickle cell anemia and experience much milder symptoms of the disease. 23andMe scientist Ruth explains the hidden genetic phenomenon happening in some bodies, and how it's already inspired real treatments. This is part 2 of our Genetic Escapers series.
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There's a real limitation in genetic research today: polygenic risk score (PRS) models are largely trained on populations of European descent, which can leave them less accurate, or simply… | 23andMe
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Sickle cell anemia is caused by a single DNA variant, and it's well understood: rigid crescent-shaped blood cells, blocked vessels and potentially organ damage.
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