According to DraftKings, Duke (+110) has the best odds to win the title entering the Final Four. Florida (+250), Houston (+400) and Auburn (+475) round out the rest of the Final Four teams. Gambling problem? Call (877-8-HOPENY) or text HOPENY (467369).

The 2025 men's NCAA Tournament Final Four is  Saturday in San Antonio. Before Auburn-Florida (6:09 ET) and Duke-Houston tip off (8:49 ET, CBS), here are five predictions for this year's national semifinals.