Objectives: Efbalropendekin alfa (EBA) (IL-15/IL-15Rα-Fc) is a Fc-fusion protein engineered to induce proliferation in NK and CD8+ T cells to boost cancer immunotherapy1. In this drug’s ongoing ...

Ski Cooper held the 51st annual 10th Mountain Day on Friday, Feb. 27. Current and past 10th Mountain Division soldiers, descendants and locals came to the mountain to celebrate the division’s history ...

Objectives: Target-Mediated Drug Disposition (TMDD) occurs when a drug binds to its pharmacological target with high affinity, leading to nonlinear pharmacokinetics. Due to the increasing number of ...

ABSTRACT: In this paper, we study a three-dimensional target-mediated drug disposition model consisted of the drugs (ligands), targets (receptors) and drug-target (ligand-receptor) complexes. In this ...

ABSTRACT: In this paper, we study a three-dimensional target-mediated drug disposition model consisted of the drugs (ligands), targets (receptors) and drug-target (ligand-receptor) complexes. In this ...

Preclinical data highlighted JADE101's femtomolar APRIL binding affinity, extended non-human primate half-life of approximately 27 days, and sustained IgA suppression In non-human primates, JADE101 ...

A phase 1 study of the OX40 agonist BGB-A445, with or without tislelizumab, an anti-PD-1 monoclonal antibody, in patients with advanced NSCLC, HNSCC, or NPC. Tumor response by CD47 non-specific cell ...

NEW HAVEN, Conn.--(BUSINESS WIRE)--Rallybio Corporation (Nasdaq: RLYB), a clinical-stage biotechnology company translating scientific advances into transformative therapies for patients with ...

Animal models play a vital role in pharmaceutical research and development by supporting the planning and design of later clinical studies. To improve confidence and reliability of first in human dose ...

Physiologically based pharmacokinetic (PBPK) modelling is an important tool to predict drug disposition in the body. Rabbits play a pivotal role as a highly valued small animal model, particularly in ...