Elizabeth Jonas first got interested in mitochondria by chance. In 1995, she was a postdoctoral researcher at Yale, working ...

Breast cancer, particularly triple-negative breast cancer (TNBC), remains a leading cause of cancer-related mortality due to ...

Members of the dynamin superfamily regulate mitochondrial fission and fusion 1,17,18 and have a similar architecture, including a large GTPase domain, a middle domain, ...

Scientists have hypothesized that the fusion and fission events are necessary to recycle the components of mitochondria ...

Scientists have hypothesized that the fusion and fission events are necessary to recycle the components of mitochondria damaged from the highly demanding process of ATP generation. That may be true.

Breast cancer, particularly triple-negative breast cancer (TNBC), remains a leading cause of cancer-related mortality due to its aggressive nature and ...

Mitochondrial dynamics in fusion-deficient Mfn1/2−/− and fission-deficient Drp1−/− MEFs were assessed for mitochondrial morphology, OXPHOS activity, and proline synthesis. Results ...

Because the deletion interferes with mitochondrial fission during fasting, this demonstrates that the mTORC2 pathway is important for this process of mitochondrial division, according to the paper.

The dynamin family of GTPases regulate mitochondrial fission and fusion processes and have been implicated in controlling the release of caspase activators from mitochondria during apoptosis. Here we ...

“In the normal, non-obese state, mitochondria maintain their health through a cycle of continual fusion and fission, which means they break apart and reform,” Dr. Saltiel explained.

Mitochondrial fission factor (MFF) works by recruiting a secondary protein ... "Mitochondrial dynamics and the correct regulation of fusion and division are critical for cell health.