A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating ...

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a ...

Affinity is one of the many confusing gameplay mechanics in Monster Hunter Wilds, and if it’s your first experience with the franchise, there are a lot of glaring stats and words you might not ...

Affinity is one of those things in Monster Hunter Wilds that isn’t well-explained, but as we’re going to demonstrate, it’s one of the core components of crafting effective builds. Affinity ...

Some of these dead cells will have died by a highly controlled process known as apoptosis. These so-called apoptotic cells display signals on their surface that nearby healthy cells recognize. This ...

Simultaneous removal of integrin β1 and α-catenin disrupts islet aggregation and the endocrine cell maturation process, demonstrating that establishment of islet aggregates is essential for functional ...

In order to provide an overview of the recently uncovered cellular and molecular mechanism during oocyte maturation, especially epigenetic modification, the progress of the regulatory network of ...

Further specialized zones of germinal centers (GC) drive maturation of the humoral response via the selection of high affinity antibodies, providing an effective source of long-lived protection in the ...

Our reanalysis supports the basic conclusion of this manuscript that peripheral mutations accumulated during affinity maturation are stabilizing, whereas binding-site mutations are destabilizing.

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