12 min read | Unique research highlights an overlooked mental health disparity among Indigenous North American people with HD – and the need for care grounded in trust, community partnership, and ...

HDBuzz has been following SKY-0515 since the first results from its Phase 1 study were announced in 2024. Early testing in ...

Long-time HDBuzz readers may recognise pridopidine. Pridopidine has had one of the longest and most winding development journeys of any experimental HD therapy. Originally developed as a treatment for ...

In plain language. Written by scientists. Roche gave an update this week about GENERATION HD2, testing the HTT-lowering drug tominersen in people with HD. The trial is continuing, but only the higher ...

Huntington’s disease (HD) is caused by an expansion of a short DNA sequence — the letters C-A-G — located in the very first part of the HTTHTT one abbreviation for the gene that causes Huntington’s ...

A new study from researchers at the University of Washington and University College London explores different ways to lower the huntingtin proteinhuntingtin protein The protein produced by the HD gene ...

August has been a packed month for Huntington’s disease (HD) research. We’ve looked at what can be learned from disappointing clinical trialclinical trial Very carefully planned experiments designed ...

Although eyesight itself is usually preserved as symptoms progress, Huntington’s disease (HD) can affect visual cognition. This means it can affect how the brain recognizes, understands, and responds ...

In plain language. Written by scientists. Skyhawk shared data at the 15 month mark for SKY-0515 treatment in people with HD in their Phase 1/2 trial. The drug is working as designed and there are some ...

In plain language. Written by scientists. Each person with HD has genetic spelling changes that can impact HD symptoms. Scientists have released the latest in a series of genetic studies examining ...

In plain language. Written by scientists. Scientists discover a rare genetic quirk that may extend the age of onset in people with Huntington’s disease by boosting cellular cleanup. A trial tested ...

In plain language. Written by scientists. Scientists engineered stem cells with “interrupted” CAG repeats to break up the toxic stretch. This may stop expansion, and could improve problems in cells ...