The idea that hypoxia alone can cause pulmonary hypertension and significant structural remodeling of pulmonary arteries (PAs) in humans is supported by observations that in persons living at high ...

Theoretical models have implicated atrial interstitial fibrosis as a substrate for AF. 8,9 Atrial interstitial fibrosis increases with age in humans and has been observed in patients with AF 10,11 and ...

Genome-wide linkage analyses for familial IA have been reported by 2 groups. 3,4 Onda et al 3 suggested linkage to regions on chromosomes 5q22–31 (maximum LOD score [MLS] 2.24), 7q11 (MLS 3.22), and ...

Methods and Results— We conducted a randomized, double-blind, placebo-controlled trial of ascorbic acid in 231 patients with a serum creatinine concentration ≥1.2 mg/dL who underwent coronary ...

Abstract Analysis of cardiovascular status in adult relatives of 116 kindred affected with familial hyperbetalipoproteinemia (type II hyperlipoproteinemia) was carried out to assess coronary artery ...

Human atherosclerotic plaques comprise inflammatory cells (macrophages and T lymphocytes), vascular smooth muscle cells (VSMCs), and intracellular and extracellular lipids. Plaque disruption results ...

Dokuchaev A, Panfilov A and Solovyova O (2020) Myocardial Fibrosis in a 3D Model: Effect of Texture on Wave Propagation, Mathematics, 10.3390/math8081352, 8:8, (1352) Huang C, Knighton N, Timmins L ...

HF decompensation is characterized by increased left atrial pressure (LAP) causing symptomatic pulmonary congestion and frank edema. 2 The possible precipitants for acute HF are numerous, but they ...

Methods and Results— Using a modification of a previously validated risk prediction model based on routine clinical variables, we examined the relationship between baseline predicted mortality risk ...

Methods and Results —Of 2792 patients enrolled, 638 (23%) were diabetic. Diabetic patients were older, shorter, and heavier; more likely to be female and have three-vessel disease, prior coronary ...

Methods and Results— In 3 Japanese family members with periodic paralysis, ventricular arrhythmias, and marked QT prolongation, polymerase chain reaction/single-strand conformation polymorphism/DNA ...

Conclusions: Together, these data identify a novel role for EphA2 in atherosclerosis, regulating both plaque inflammation and progression to advanced atherosclerotic lesions. Cell culture studies ...