There were approximately 725,000 new cases and 664,000 deaths worldwide due to hepatocellular carcinoma (HCC) in 2020. HCC comprises 75%-85% of primary liver cancer cases and is the fourth-leading ...

Computational Modeling for Circulating Cell-Free DNA in Clinical Oncology A comprehensive search was conducted in PubMed, Web of Science, and OpenAlex for literature published between December 1, 2022 ...

The cancer fusionome and overexpressed druggable oncogenic signals in K-RAS wild-type pancreatic cancer. Delivery of B7H3-targeted CAR-T cells in injectable silk hydrogels and effects on the efficacy ...

Depending upon prior treatment received, androgen receptor pathway inhibitors (ARPIs: enzalutamide, abiraterone with prednisone), poly(ADP-ribose) polymerase inhibitors (PARPi), chemotherapeutic ...

PCS involves extensive surgical effort to achieve optimal debulking, defined as no residual tumor or minimal residual disease. This approach has been associated with improved survival rates when ...

Fig 1.Management of the axilla for patients with clinical T ≤2 cm breast cancer. a Multidisciplinary discussion of adjuvant therapy options should occur prior to surgery when omitting sentinel lymph ...

Neuroendocrine neoplasms (NENs) include poorly differentiated neuroendocrine carcinomas, well-differentiated neuroendocrine tumors (NETs), and mixed neuroendocrine non-NENs. 1 The focus of this ...

The therapeutic landscape for metastatic hormone-sensitive prostate cancer (mHSPC) includes combination therapies with two agents (previously referred to as doublet therapy or doublets), such as ...

The cyclin-dependent kinase 4/6 (CDK4/6) inhibitors palbociclib, abemaciclib, and ribociclib each showed a significant or strong trend to improve overall survival (OS) when given as second-line ...

Axillary staging for breast cancer has been a standard part of initial surgical treatment since 2002 when Fisher et al published the National Surgical Adjuvant Breast and Bowel Project (NSABP) B06, 1 ...

Our previous NECO phase II studies on high-grade osteosarcoma suggested that administering ifosfamide (IF; 16 g/m 2 [4g/m 2 once on day 1, then 2g/m 2 once on days 2-7] × six) to patients showing a ...

ASCO first published evidence-based clinical practice guidelines on FP in 2006, and published updated guidelines in 2013 5 and 2018. 6 This guideline update provides a comprehensive approach to ...