The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and communication between the gut microbiota and the nervous system.

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system caused by the immune system. B cells, which are a type of white blood cell, play a role in the development of MS ...

Two genes are associated with three types of MLC. Type 1 (OMIM 604004) is caused by a recessive mutation in MLC1 (OMIM 605908), type 2A (OMIM 613925) is caused by a recessive mutation in HEPACAM (OMIM ...

However, in the case of MLC disease, as MLC1 and GlialCAM proteins are located in the cellular membrane of astrocytes, we might need to transduce as many astrocytes as possible. Figure 3.