POLG-related diseases disrupt the function of the mitochondria, or "powerhouses" of the cell — starving them of energy.

Prince Frederik, 22, was a founder and the creative director of a foundation that raised awareness of POLG disorder.

The prince had PolG disease, a genetic mitochondrial disorder that prevents the body's cells from producing adequate energy.

Luxembourg's Royal Family has announced the death of Prince Frederick at 22 years old.

Prince Frederik of Luxembourg, who died at 22, spoke about the rare genetic disorder he navigated in a video released by The PolG Foundation he founded.

Prince Frederik of Luxembourg, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, has died after a lifelong battle with a rare genetic disorder known as POLG mitochondrial disease.

Prince Frederik, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, died at age 22 on March 1 from the rare genetic condition POLG Mitochondrial disease.

Prince Frederik, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, has died at the age of 22. He passed away on March 1 from POLG Mitochondrial disease, a rare genetic disorder.

Prince Frederik of Luxembourg died from a genetic disease called PolG, but experts hope his passing could bring more awareness to the rare condition that impacted his life. Prince Frederik, 22, died from a mitochondrial disease known as PolG,