Genome-wide linkage analyses for familial IA have been reported by 2 groups. 3,4 Onda et al 3 suggested linkage to regions on chromosomes 5q22–31 (maximum LOD score [MLS] 2.24), 7q11 (MLS 3.22), and ...

Methods and Results— We conducted a randomized, double-blind, placebo-controlled trial of ascorbic acid in 231 patients with a serum creatinine concentration ≥1.2 mg/dL who underwent coronary ...

Abstract Analysis of cardiovascular status in adult relatives of 116 kindred affected with familial hyperbetalipoproteinemia (type II hyperlipoproteinemia) was carried out to assess coronary artery ...

Human atherosclerotic plaques comprise inflammatory cells (macrophages and T lymphocytes), vascular smooth muscle cells (VSMCs), and intracellular and extracellular lipids. Plaque disruption results ...

Dokuchaev A, Panfilov A and Solovyova O (2020) Myocardial Fibrosis in a 3D Model: Effect of Texture on Wave Propagation, Mathematics, 10.3390/math8081352, 8:8, (1352) Huang C, Knighton N, Timmins L ...

HF decompensation is characterized by increased left atrial pressure (LAP) causing symptomatic pulmonary congestion and frank edema. 2 The possible precipitants for acute HF are numerous, but they ...

Methods and Results— Using a modification of a previously validated risk prediction model based on routine clinical variables, we examined the relationship between baseline predicted mortality risk ...

Methods and Results —Of 2792 patients enrolled, 638 (23%) were diabetic. Diabetic patients were older, shorter, and heavier; more likely to be female and have three-vessel disease, prior coronary ...

Methods and Results— In 3 Japanese family members with periodic paralysis, ventricular arrhythmias, and marked QT prolongation, polymerase chain reaction/single-strand conformation polymorphism/DNA ...

Conclusions: Together, these data identify a novel role for EphA2 in atherosclerosis, regulating both plaque inflammation and progression to advanced atherosclerotic lesions. Cell culture studies ...

Background—Although frequently assessed in trials and clinical practice, hemodynamic response to therapy has never been validated as a surrogate end point for clinical events in pulmonary arterial hy ...

Atherosclerosis remains a major health problem in the United States, with significant morbidity and an estimated annual mortality of 500 000 deaths from coronary artery disease alone. 1 The lesions in ...