Sandy Alcantara, the Marlins ace, allowed a leadoff hit to Pedro Ramirez in the ninth, but got Swanson to fly out and pinch-hitter Carson Kelly to ground into a double play, earning his second save in a week.

A comprehensive preview, including betting odds and predictions, for the MLB game between the Miami Marlins and Chicago Cubs.

Photos from the Chicago Cubs’ 8-2 loss to the Miami Marlins in 12 innings at Wrigley Field on Tuesday, Sept. 22, 2026.

BOTTOM LINE: The Chicago Cubs host the Miami Marlins to start a three-game series. Chicago has an 87-69 record overall and a 45-33 record in home games. The Cubs are 24-10 in games when they did not allow a home run.

The Marlins lost again to the Cubs, as their wild card playoff hopes continue to dim.

The Chicago Cubs visit the Miami Marlins open up a 3-game series Friday with a 7:10 p.m. ET first pitch at Loan Depot Park in Miami, Florida.

The Chicago Cubs had a fantastic opportunity to clinch a playoff spot Tuesday night against the Miami Marlins, but lost in 12 innings.

Find the latest odds, spread and score prediction for the Chicago White Sox vs. Kansas City Royals MLB game on ESPN to be played on September 23, 2026 on ESPN.