Duke, Florida, Houston and Auburn are headed to San Antonio as the Final Four will be comprised of four No. 1 seeds for just the second time in NCAA Tournament history. Whether you're sticking it out in your office pool or need clean brackets for the next round and into the Final Four,

What are Final Four odds now? What to know about Houston Cougars vs Duke Blue Devils point spread, moneyline, over/under for March Madness betting.

The ACC was down bad this year and that's where Duke accumulated many of its numbers. Sure, the Blue Devils had non-conference wins, including against Auburn and Arizona, but wasn’t the Big 12 a lot better than the ACC this year? And Houston ripped through it, barring an OT loss to Texas Tech, which really should be playing this weekend.