The Clemson Tigers (3-4) square off against a conference opponent when they host the Duke Blue Devils (4-3) on Saturday, Nov. 1, 2025 at Memorial Stadium (Clemson, SC) in an ACC clash. Date: Nov. 1 Our team of savvy editors independently handpicks all recommendations.

Clemson loses to Duke for yet another home loss after a wild end to the game and a questionable pass interference call.

In the last four decades, Duke has seen football success on occasion. Coaches Steve Spurrier and Fred Goldsmith enjoyed productive years; David Cutcliffe won 10 games and a division title; Mike Elko rode success with the Blue Devils to his current post at Texas A&M.

Duke's climactic first win at Clemson in 45 years featured four touchdown passes and 361 yards passing from Darian Mensah, who gave the Blue Devils the lead with a successful 2-point conversion with 40 seconds to play on a bootleg toss to Sahmir Hagans.