Rounding out the afternoon in the late window for Week 5 will be Tennessee at Arizona, Detroit in Cincinnati, taking on the Bengals, and Washington visiting the West Coast to face the Los Angeles Chargers. It's Week 5, and the NFL is down to its final two undefeated teams in the Eagles and Buffalo Bills.

Week 5 of the 2025-26 NFL regular season officially gets underway on Thursday, October 2, with a Thursday Night Football primetime clash featuring the NFC West rival San Francisco 49ers and Los Angeles Rams at SoFi Stadium.

Some of the site's predictions differ from NFL Week 5 odds and other NFL Week 5 picks for NFL Week 5 games. How correct will the analytics be this week? Click on each game for more NFL Week 5 predictions for that NFL matchup. All times MST. The site allows for the possibility of ties, so the numbers add up to just less than 100%.

The Baltimore Ravens are limping into a Week 5 matchup with the visiting Houston Texans, missing five All-Pro players. Quarterback Lamar Jackson, linebacker Roquan Smith, and safety Kyle Hamilton are all out for Sunday's game with hamstring injuries.

The San Francisco 49ers versus the Los Angeles Rams is one of many strong options on the Week 5 NFL slate. With Week 5 in the NFL upon us, stay on top of the latest betting odds with our preview below.

One month of the 2025-26 NFL regular season is in the books, and now it's time to kick off October with Week 5 set to kick off on Thursday, October 2, with an NFC West showdown in primetime. The action gets underway in primetime on Prime Video when the Los Angeles Rams welcome the

Los Angeles is right in the race for the NFC West crown in the 2025 NFL season. Here's what's on deck for the team in Week 8.

When the sun rises on a sixth straight NFL Sunday, it shines on a league with zero undefeated teams remaining. Both of the last unbeaten teams – the Philadelphia Eagles and Buffalo Bills – suffered their first losses on Sunday of Week 5. Both losses ...

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 43-28 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.