In that scenario, Seattle would be at 11-3 and take the No. 1 seed, while the Rams would slide to 10-4. A 49ers win over the Colts bumps them to the No. 5 seed, while the Rams would fall to No. 6 due to their divisional record (4-1 for the 49ers vs. 3-2 for the Rams).

NFL.com's Eric Edholm breaks down three must-know storylines for Thursday's huge NFC West game between the Los Angeles Rams and Seattle Seahawks.

New England's close loss to the Buffalo Bills on Sunday, Dec. 14, opened the door for a new team to take over the top spot in our NFL Week 16 power rankings, the first time this team has sat atop our power rankings this season.

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An ESPN analyst believes the 49ers can make noise in the playoffs, but one fatal flaw could derail San Francisco's postseason hopes.

Pregame analysis and predictions of the Los Angeles Rams vs. Seattle Seahawks NFL game to be played on December 18, 2025 on ESPN.

How Seahawks, Patriots, Jaguars, Chargers, Bills, Bears, 49ers, Eagles, Packers can clinch NFL playoff berths this week. See NFL clinching scenarios.