Accurate duplication of the genome is fundamental to cellular viability and prevention of disease. Replicative DNA polymerases achieve high fidelity through three interconnected mechanisms: intrinsic ...

Archaeal replication systems employ two principal families of polymerases, designated PolB and PolD, to duplicate genomes with exceptional accuracy and efficiency. Each polymerase comprises a ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...