In a study posted to the bioRxiv* preprint server, researchers studied the preclinical pharmacokinetics (PK) and in vitro absorption, distribution, metabolism, and elimination (ADME) properties of ...

Pharmacokinetics in neonates examines the unique processes of absorption, distribution, metabolism, and excretion that govern drug behaviour in this vulnerable population. Owing to rapid physiological ...

Commercially launched in the U.S. in November 2025, TONMYA (cyclobenzaprine HCl sublingual tablets) for long-term daily dosing at bedtime is the ...

Purpose Pharmacokinetic considerations in patients who have undergone Roux-en-Y gastric bypass (RYGB) are explored. Summary The prevalence of obesity, especially morbid obesity, has dramatically ...

Severe visual illnesses are increasing in our society, and effective treatments are missing for diseases as age-related macular degeneration, diabetic retinopathy, and glaucoma. Both industry and ...

T-cells targeted with anti-CD3 x anti-HER2 bispecific antibody for treatment of women with stage IV breast cancer (phase I): Clinical and immune function results. This is an ASCO Meeting Abstract from ...

Though studies evaluating the effects of posture on the absorption of drugs have been conducted, a systematized review revealed critical gaps in methodology. Of 18 original research articles selected ...

The landscape of drug development is rapidly evolving, with a pressing need for innovative strategies that account for the intricacies of individual patient responses. Pharmacokinetics, the study of ...

The Molecular Screening and Therapeutics (MoST) Program: A precision medicine framework for biomarker-driven signal-seeking clinical studies for rare cancers. EGFR/CD16A tetravalent bispecific ...

Drug metabolism and pharmacokinetic (DMPK) profiles of prospective new drugs must be evaluated for properties such as bioavailability, half-life, clearance and metabolic profile. Drug metabolite ...

Neuroinflammation drives the progression of neurodegenerative disorders like Alzheimer's, Parkinson's, and multiple sclerosis ...