Different types of cancer have unique molecular "fingerprints" which are detectable in early stages of the disease and can be picked up with near-perfect accuracy by small, portable scanners in just a ...

Full-length lincRNAs were assembled from ONT long-read RNA-seq data, enabling the identification of lincRNAs activated under DNA methylation-deficient conditions. To further characterize these ...

One of the challenges in clinical genetics for rare diseases, especially in the era of personalized medicine, is assessing the effect of putative splicing variants on isoform expression in ...

Comparison of conventional B-cell acute lymphoblastic leukemia (B-ALL) fusion diagnostics (top) and Nanopore-based fusion detection (bottom). Current diagnostics involve multiple tests, whereas ...

Whole genome sequencing (WGS) is not necessarily a solution for someone with a rare, monogenic disease. Indeed, more than half of families with suspected rare monogenic diseases do not have an answer ...

Oxford Nanopore Technologies is looking forward to “the year of the proteome,” as co-founder and CEO Gordon Sanghera, PhD, labeled 2025 during his presentation at the recent 43rd Annual J.P. Morgan ...

The researchers working on this new tool have previously demonstrated the use of nanopore RNA sequencing to classify B-ALL. Now, the sensitive and accurate method for detecting gene fusion subtypes ...

The researchers working on this new tool have previously demonstrated the use of nanopore RNA sequencing to classify B-ALL. Now, the sensitive and accurate method for detecting gene fusion subtypes ...

A pioneering partnership between researchers from The Grainger College of Engineering at the University of Illinois Urbana-Champaign has produced a novel nanopore sensing platform for ...

Researchers have introduced a novel diagnostics method that can more sensitively detect gene fusions in B-cell acute lymphoblastic leukemia (B-ALL), the most common type of pediatric cancer, compared ...