The continuous fusion and fission of mitochondria is important for their inheritance and function. The core components of the fusion and fission machineries, and the mechanisms that regulate these ...

Most mitochondrial proteins, including all those involved in fission and fusion, are nuclear-encoded. 4 Mutations in 228 nuclear and 13 mitochondrial genes cause rare monogenic syndromes in which ...

Mitochondrial fission and fusion are known to play roles in maintaining the (1) integrity of mitochondria, (2) electrical and biochemical connectivity, (3) turnover of mitochondria, and (4 ...

Breast cancer, particularly triple-negative breast cancer (TNBC), remains a leading cause of cancer-related mortality due to ...

Rather than being like battery chargers, mitochondria are more like the motherboard of the cell.

Scientists have hypothesized that the fusion and fission events are necessary to recycle the components of mitochondria ...

Breast cancer, particularly triple-negative breast cancer (TNBC), remains a leading cause of cancer-related mortality due to its aggressive nature and ...

Scientists have hypothesized that the fusion and fission events are necessary to recycle the components of mitochondria damaged from the highly demanding process of ATP generation. That may be true.

Mitochondrial fission factor (MFF) works by recruiting a secondary protein (DRP1) to the mitochondria to encourage division.

Because the deletion interferes with mitochondrial fission during fasting, this demonstrates that the mTORC2 pathway is important for this process of mitochondrial division, according to the paper.

Mitochondrial dynamics in fusion-deficient Mfn1/2−/− and fission-deficient Drp1−/− MEFs were assessed for mitochondrial morphology, OXPHOS activity, and proline synthesis. Results ...

“In the normal, non-obese state, mitochondria maintain their health through a cycle of continual fusion and fission, which means they break apart and reform,” Dr. Saltiel explained.