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Oral cancer pain and opioid tolerance share a common EGFR mechanism

Epidermal growth factor receptor (EGFR) signaling in the tissue around oral cancers both increases nerve sensitivity and ...
News Medical

Uncovering the neurobiological mechanisms of delta opioid receptor agonists

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to treat these conditions, current medications have several limitations, ...
Houston Chronicle

How does Narcan work? Mapping how it reverses opioid overdose can provide a molecular blueprint for more effective drugs

(THE CONVERSATION) Naloxone, also known by the brand name Narcan, is one of the most important drugs in the United States’ fight against the opioid crisis. It reverses an opioid overdose nearly ...
Science Daily

Uncovering anxiety: Scientists identify causative pathway and potential cures

Quick-acting targeted therapies with minimal side effects are an urgent need for the treatment of anxiety-related disorders. While delta opioid receptor (DOP) agonists have shown 'anxiolytic' or ...

Adolore BioTherapeutics Announces FDA Orphan Drug Designation for its Kv7-activating rdHSV-CA8* Therapy in the Treatment of Erythromelalgia

Orphan Drug Designation applies to approximately 50,000 Patients who predominantly suffer from severe chronic pain due ...
Times Union

How does Narcan work? Mapping how it reverses opioid overdose can provide a molecular blueprint for more effective drugs

(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) Saif Khan, USC Dornsife College of Letters, Arts and Sciences (THE CONVERSATION) ...