In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists have recently identified the mechanism behind regulated splicing of large constitutive exons which ...

Researchers at McGill University have developed a machine learning tool that identifies disease-related patterns in RNA expression at a finer resolution than conventional methods.

In amyotrophic lateral sclerosis and frontotemporal dementia, loss of the RNA-binding protein TDP-43 from the nucleus creates a surge of mis-spliced mRNAs in neurons. So far, only one of these errant ...

This article was review by Thomas Cooper, MD from Baylor College of Medicine. Stay up to date on the latest science with Brush Up Summaries. Located throughout the pre-mRNA are short, cis-acting ...

In TDP-43 proteinopathies, the RNA/DNA binding protein leaves its post in the nucleus and travels to cytosol, where it’s prone to aggregate. This meandering allows mis-spliced transcripts to ...

In a new study, researchers demonstrate that deregulation of a protein called RBFOX2, involved in RNA splicing, contributes to the progression and metastasis of pancreatic cancer. Pancreatic cancer ...

Alternative splicing (AS) is a key technique for increasing transcriptome and proteomic diversity from a small genome. Almost all human gene transcripts are alternatively spliced, resulting in protein ...

Spinal muscular atrophy (SMA) is a genetic disorder that is caused by the absence of the survival of motor neurons 1 (SMN1) protein-encoding gene on chromosome 5 (5q13). This is present in all cells ...

In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists from Nagoya University, Japan, led by Associate Professor Akio Masuda, have recently identified the ...