A review discussing the therapeutic potentials of NK cell biology has been published in the journal Frontiers of Medicine. This exhaustion is influenced by immune checkpoint receptors, which are ...

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

T cell checkpoint modulation harnesses or inhibits natural regulatory pathways that control T cell activation, proliferation and survival. Central to this approach are inhibitory receptors such as ...

Checkpoint inhibitors are antibody-based cancer therapies that unlock the immune system’s natural ability to fight cancer. These treatments work by blocking special proteins called immune checkpoints, ...

Skin cancers, lung cancers, lymphomas—though these cancers affect different parts of the body, they can all be treated with one of the latest therapies medicine has to offer: checkpoint inhibitors.

A new comprehensive review reveals that harnessing natural killer (NK) cells by blocking their “off-switches” could significantly enhance cancer immunotherapy, providing new avenues for treating solid ...

A study published in Cell Research advances a central idea in stem cell biology by identifying a checkpoint that controls the identity of many different types of stem cells across developmental stages ...

Yale researchers have uncovered a way to make a type of white blood cells known as natural killer cells—which kill infected, damaged, or malignant cells in the body—more effective against cancer. The ...

Hearn Jay Cho, MD, explains how immune profiling could inform what impairs T-cell fitness, a crucial consideration when using CAR T-cell therapy or bispecific T-cell engagers. Hearn Jay Cho, MD, PhD, ...

It's the cancer-fighting immune cells in a Merkel cell carcinoma patient's blood — not their tumor — that best predicts whether a certain type of immunotherapy will work, according to new work from ...