A day before the 49ers earned their 10th win of the year, it was reported that the team will officially be without wide receiver Brandon Aiyuk for the remainder of the 2025 season. The 49ers have placed Aiyuk on the reserve/left squad list, making him ineligible to return to the team this season.

It has been nearly 14 months since the Pro Bowler last appeared in a game for the Niners. His 2024 season ended prematurely with the torn ACL, but he was expected to come back this season and provide the downfield threat that earned him his four-year, $120 million contract, which was acquired in its own contentious process.

ESPN's Jeremy Fowler is pointing to the Washington Commanders as a possible option for Brandon Aiyuk if he gets released.

It's clear the 49ers are relying on Pearsall to become Aiyuk's successor in the receiving corps — this season and in the future.

"The 49ers today put Brandon Aiyuk on the reserve/left squad list, which officially ends his 2025 season. The reserve/left squad list is usually applied to players who plan to retire or who have quit their team," The Athletic's Matt Barrows wrote.

The Athletic's Dianna Russini is expecting an answer in the near future as to whether Brandon Aiyuk will play another game for the San Francisco 49ers.

Brandon Aiyuk’s ties to Jayden Daniels are fueling Commanders rumors as the team weighs its offseason plans around their injured QB.